Gut Check: AI and Genomic Literature

Published

June 2, 2026

Overview

These questions focus on the critical approach scientists must use to evaluate the validity of information, including information provided by Large Language Model (LLM) chat sources.

Build Your Query

First, select one of the following topics:

  • Differential expression

  • Epigenetics

  • Ethical considerations in genomic research

  • Genomic databases

  • Genomic medicine

  • The gut-brain axis

  • Hardy-Weinberg Equilibrium

  • Human pedigrees with family markers

  • Polygenic risk scores

  • Population genetics

  • RNAseq

Next, insert your topic into the following:

Explain the meaning and significance of ______. Include references.

Finally, submit the completed query to the chatbot of your choice (e.g., ChatGPT, Claude, etc.)

Questions

NoteEvaluate Evidence

  1. Examine the references provided by the chat’s response. Can you find an original source online? Who is presenting the source? Consider: individual and organization qualifications, conflict of interest, and trustworthiness.

  2. For references that link to a scientific article, what is the take home message? Does it match the statement made by the chatbot’s response? Is it relevant and sufficient? Consider: the article’s abstract (if present).

  3. How does the chatbot’s response compare with other reliable sources? What do the experts say?

  4. How does the chatbot’s response and evidence make me feel? Is this what I already believed before I read it? What might make me change my mind?